PFP or Cyano

[dudumaurina]

Hello guys!

I'm trying to separate compounds from the reaction of acetylation of glycerol, triacetin, diacetin and monoacetin. I'm going to buy a new column for my HPLC and I don't know if I should get a PFP (Pentafluorophenyl) or a Cyano. I talked to one of my teachers and she thinks that glycerol might get stuck in the PFP, so she thinks that the cyano might be a better choice. But I think that the PFP will give me a better separation. What do you guys think?

Thanks!

[Kreall]

In my opinon PFP columns are rather used for separation of aromatic and halogenated compounds. You compounds are neither aromatic nor halogenated.
For polar compounds the Cyano and amino columns are suggested. I probably would try a HILIC separation, but this is you choise.

[dudumaurina]

PFP is used for compounds that have double bonds and/or can do hydrogen bonding, they are not only used for halogenated and aromatic compounds.