Use of inorganic salts in GC solvents
Posted: Mon Jul 27, 2015 8:55 pm
What is the purpose of using inorganic salts (sodium chloride, sodium dihydrogen phosphate etc.) in GC solvents for analyzing residual solvents in APIs?
Chromatography Forum
Chromatography Forum is a public discussion group where you can post questions, news, or messages of interest to chromatographers everywhere, but you must be registered to participate (registration is FREE). If you are a registered user, please log in.
http://www.chromforum.org/
Use of inorganic salts in GC solvents
Page 1 of 1
Re: Use of inorganic salts in GC solvents
Posted: Tue Jul 28, 2015 2:25 am
The only reason to add salts to samples in chemical analysis to me is to make the matrix inhospitable for the analyte. You add salt to water solutions to drive a somewhat water soluble analyte into the headspace to improve the detection limit. You add salts to water to drive analytes into the organic solvent you're using to extract the analyte from the sample, etc.
Re: Use of inorganic salts in GC solvents
Posted: Tue Aug 11, 2015 4:54 pm
The only reason to add salts to samples in chemical analysis to me is to make the matrix inhospitable for the analyte. You add salt to water solutions to drive a somewhat water soluble analyte into the headspace to improve the detection limit. You add salts to water to drive analytes into the organic solvent you're using to extract the analyte from the sample, etc.
