TETA (Method OSHA 60) mobile phase alternatives?

[passy]

Hello all,

Lurk from time to time but don't post often...

I've been given some tubes to analyse for triethylenetetramine in air - they're XAD coated with a napthylisothiocyanate derivitising agent.

The OSHA method the client followed:

https://www.osha.gov/dts/sltc/methods/o ... rg060.html

It has a pretty awful mobile phase (50% isoctane/IPA) and would really like to avoid changing our system over to normal phase for a one-off.

Anyone have any happier alternatives? I found a HILIC method but it still has plenty of octane and ipa in it as well.

Thanks in advance.

David

[mattmullaney]

Hi David,

Unfortunately there don't seem to be any readily available alternatives for the application you note. From this link:

http://www.sciencedirect.com/science?_o ... c38ab415ca

there may be three papers you could read, none of which employ napthylisothiocyanate.

Hopefully someone out there will do better than I have. This one:

Journal of Chromatography B, Volume 860, Issue 1, 1 December 2007, Pages 92–97

is vaguely related only, but it may help, I'm not sure.

Best wishes...tough nut to crack, this one.

[passy]

Thanks for the reply Matt.

I've subsequently found a couple of application notes from Dionex using %100 MeOH with formic acid. One of the columns were a proprietary C30 job but another was a monomeric 'high density' C18.

Pretty sure we have one of these around - or something like it - will try some standards tomorrow.