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Boric acid determination
Posted: Fri May 08, 2015 9:13 am
by gnikol21
Hello to all, i need to find a method (pref HPLC) to measure the boric acid content in a opthalmic drug product. Can anyone have any suggestion?
Thnx in advance
Re: Boric acid determination
Posted: Fri May 08, 2015 10:56 am
by Fernando
Hi gnikol21
What detectors are available to you? I think a conductometric detector would be the choice.
See the Phenomenex site for a method.
Best regards
Fernando
Re: Boric acid determination
Posted: Fri May 08, 2015 12:28 pm
by gnikol21
We have RI detector so i think i can try couple of methods i found in a quick search in internet.
Thnx Fernando
Re: Boric acid determination
Posted: Sat May 09, 2015 3:57 pm
by Alfred88
Dear gnikol21.
What is the reason why you need to determine Boric acid? It is not a DS/API.
Are you trying to reverse-engineer the buffer system of a branded product?
You can try to do a simple titration to find the desired ratio of Boric acid/Sodium borate to reach certain pH value.
Alfred
Re: Boric acid determination
Posted: Sun May 10, 2015 3:54 am
by Consumer Products Guy
Dear gnikol21. What is the reason why you need to determine Boric acid?
In my case, we'd like to determine borates, used in some laundry detergents. Typically, we just send out for ICP analysis for boron, turns out to be cheaper, and gives us silicon level too, also of interest.
Re: Boric acid determination
Posted: Mon May 11, 2015 6:46 am
by Kreall
Shodex Rspack KC-811 or equivalent
Mobile phase: 5 ml HCLO4 0,1N (in CH3COOH)
flow rate 1,0 ml/min
column temp: 40C
detection: RI