Reporting of LOD and LOQ in validation

[jayroseville58]

LOD and LOQ can be identified by standard deviation method and thru signal-to-noise ratio method. As per ICH guideline linearity for the RS method should be established from LOQ. Is it allowable that LOQ used here will be based from the S/N method while the values to be reported for the LOD and LOQ should be based from standard deviation method (derived from the linearity curve)? Thanks.

[Alfred88]

There are several approaches to estimate LOD or LOQ. If you have data, you can construct a linear curve of standards, then calculate (estimate) LOD using standard deviation of intercept.
Then you can prepare solution at the target LOD to confirm your estimate.
Alfred.