Detector out resistance effect on peak width.

[Johte]

Good Morning,

I was told I could decrease my peak width in a nanoflow instrument by increasing the resistance of flow ( with length of silica line ) of detector out that I can prevent diffusion of my eluted bands. If someone could link me to some literature on the subject it would be most helpful.

Thank you.

[kubowicz.tomasz]

Hello

Be careful with installing any restriction in detector outlet - you can damage detector cell if pressure will be to high (check limit for cell).

Regards

Tom