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Completely aqueous mobile phase in ESI-MS

http://www.chromforum.org/viewtopic.php?t=26585

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Completely aqueous mobile phase in ESI-MS

Posted: Tue Mar 31, 2015 8:15 am
by pfjl
Is it ok to use completely aqueous mobile phase in ESI-MS (0.1 % FA in water)? Would it hurt the source?

Piotr

Re: Completely aqueous mobile phase in ESI-MS

Posted: Wed Apr 01, 2015 1:55 pm
by carlo.annaratone
no problems with the source (as long as it is only formic acid or other volatile additive). You will have reduced signal compared to mixed water/organic injections

Re: Completely aqueous mobile phase in ESI-MS

Posted: Thu Apr 02, 2015 9:05 pm
by James_Ball
Just be sure the the temperature is high enough to ensure that the water becomes vapor and you don't get condensation on the cone.

Re: Completely aqueous mobile phase in ESI-MS

Posted: Fri Apr 03, 2015 8:48 am
by pfjl
@carlo.abbaratone & @James_Ball

Thanks for your answers!

Piotr
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