Advertisement
Chromatography Forum

Completely aqueous mobile phase in ESI-MS

Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.

4 posts Page 1 of 1
Post a reply

Completely aqueous mobile phase in ESI-MS

avatar
pfjl
Is it ok to use completely aqueous mobile phase in ESI-MS (0.1 % FA in water)? Would it hurt the source?

Piotr

Re: Completely aqueous mobile phase in ESI-MS

avatar
carlo.annaratone
no problems with the source (as long as it is only formic acid or other volatile additive). You will have reduced signal compared to mixed water/organic injections

Re: Completely aqueous mobile phase in ESI-MS

avatar
James_Ball
Just be sure the the temperature is high enough to ensure that the water becomes vapor and you don't get condensation on the cone.
The past is there to guide us into the future, not to dwell in.

Re: Completely aqueous mobile phase in ESI-MS

avatar
pfjl
@carlo.abbaratone & @James_Ball

Thanks for your answers!

Piotr
Post a reply
4 posts Page 1 of 1
Return to “LC-MS, GC-MS, and other”

Who is online

In total there are 13 users online :: 0 registered, 0 hidden and 13 guests (based on users active over the past 5 minutes)
Most users ever online was 4374 on Fri Oct 03, 2025 12:41 am
Users browsing this forum: No registered users and 13 guests

Latest Blog Posts from Separation Science

Separation Science offers free learning from the experts covering methods, applications, webinars, eSeminars, videos, tutorials for users of liquid chromatography, gas chromatography, mass spectrometry, sample preparation and related analytical techniques.

Subscribe to our eNewsletter with daily, weekly or monthly updates: Food & Beverage, Environmental, (Bio)Pharmaceutical, Bioclinical, Liquid Chromatography, Gas Chromatography and Mass Spectrometry.

Liquid Chromatography

    Gas Chromatography

      Mass Spectrometry