Robustness test for Related Substance

[jayroseville58]

Can I use Change in Detector for Robustness Test? Is it okay if I'm going to use PDA detector first and changing it into 2487 UV/VIS detector? Thanks.

[dlbenach]

I would say no. Changing the detector is changing the method. Robustness should only alter the method conditions.

[max_planck]

Can I use Change in Detector for Robustness Test? Is it okay if I'm going to use PDA detector first and changing it into 2487 UV/VIS detector? Thanks.

Of course you can! This way you will have established method robustness over both UV-detector models. Especially in the future as you might need to transfer the method to another laboratory with PDA/DAD detectors only.