GC-MS direct probe - any contamination effects?

[hplc.chem]

Dear Colleagues,
We bought a Single Quadrupole GC-MS for our main applications involving sensitive analyses of environmental and food contaminants.

Some organic synthesis and natural products colleagues are interested in getting MS data for their new synthesized/extracted compounds. They suggested buying a direct sample injection probe that introduces both solid and liquid samples into the MS ion source, without using the gas chromatograph.

I am reluctant to purchase this probe as I have a concern that it may contaminate the MS and affect the sensitivity of the system towards the low level analyses.

How do you think the direct probe may affect the low level analyses?
Is the single quad good enough to produce MS data for organic synthesis chemists and for natural products applications? If not, what system serves better for them?

Many thanks in advance.

[Amirav]

HPLC-Chem
Which GC-MS model did you purchase?
Direct insertion probe can accidently bring pieces of sample powder into the ion source, resulting in long time "memory".
The cleanest MS probe is the ChromatoProbe (Bruker name) or Thermal Separation Probe (TSP) by Agilent and you can look at its different concept of operation at the Agilent website.
The best GC-MS for the provision of MS data for organic synthesis chemists is the Aviv Analytical 5975-SMB that upgrades Agilent 5975/7 into GC-MS with Cold EI. It doubles the size of compounds that can be analyzed, enhances the molecular ions, provides elemental formula with TAMI software, the analysis takes only a few minutes and its uniform response enables the provision of chemical reaction yields.
You can look at four relevant app notes in http://blog.avivanalytical.com/search/l ... %20by%20MS
I will be happy to Email you further information on any of the above
Amirav
amirav@tau.ac.il

[CE Instruments]

No mention of the MS that you have bought
Can we assume that a probe is available ? How does it interface to the MS ? Do you have a vacuum interlock to allow fast change between GC and probe ? I have seen systems that require the GC to be removed
You don't say what your low levels are and how they relate to the compounds the chemists want a probe for ? Can you trust them to make a pure compound or will it still have solvent residues ?

If they want a purity check and an MS to confirm they have made what they want then provided the compound GCs it is much better to dilute and shoot

[hplc.chem]

Many thanks for all and sorry for the missing details.

The GC-MS is a Shimadzu QP2010 Ultra as detailed below:
http://www.ssi.shimadzu.com/products/pr ... ct=qpultra

and the Probe is a direct DI-2010:
http://www.ssi.shimadzu.com/products/pr ... ct=di-2010

The probe is still not available and my colleagues want to buy it for their applications in organic synthesis.

Does any one have used this combination?