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Analysis of Bisoprolol hemifumarate

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Analysis of Bisoprolol hemifumarate

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Provetech
Hi, we're trying to replace Perchloric acid buffer by an volatile one for the LC/MS analysis of Bisoprolol hemifumarate. Could anyone tell me what buffer i should try (TFA buffer dont give good peak shape)
PS: Concentration is 2mL/L of perchloric acid.

Thanks

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Mark Tracy
Have you considered longer-chain perfluoro acids? pentafluoropropionic or heptafluorobutyric?
Mark Tracy
Senior Chemist
Dionex Corp.
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