Advice on quantification with hexadecane

[AA11]

Currently, I'm using a GC-MS with a HP-5 column to quantify phenol and cyclohexanol which does a good job with quantification in methylene chloride solvent by itself. I am running reactions in hexadecane which is not a good solvent for phenol or cyclohexanol and am using toluene as a co-solvent, but I am having issues with injection repeatability on 75% of my samples. The liner has been changed out and so has the inlet septum. The column is free of obstruction. I have tried to run at a higher inlet temp (310 deg C), but the signal of the low boiling pt components is bad. Is there a way I can get good quantification of phenol and cyclohexanol using the GC? Will I have to use a solvent that is immiscible in hexdecane for quantification? Would LC be a better choice?

Thanks for any suggestions.

[Consumer Products Guy]

Would LC be a better choice?

No, I think GC is a better choice. If you "must" have hexadecane in your matrix, if me I'd try diluting/disssolving all in DMF, keep your column type as it is.

We've used hexadecane successfully as solvent when assaying high-boiling paraffins.

[AA11]

Would LC be a better choice?

No, I think GC is a better choice. If you "must" have hexadecane in your matrix, if me I'd try diluting/disssolving all in DMF, keep your column type as it is.

We've used hexadecane successfully as solvent when assaying high-boiling paraffins.

So you are inferring that Hexadecane will cause issue with quantification?

[Consumer Products Guy]

So you are inferring that Hexadecane will cause issue with quantification?

No.