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Ethylene oxide residue in medicine products by GC
Posted: Fri Oct 31, 2014 3:05 am
by thohry
Hi all,
Anyone have the idea how to analyze EO residues in medicine products (polymer) by headspace GC. Some products are rather large, should I cut them into pieces and by that way, is it possible that the residues can escape ?
Thanks
Re: Ethylene oxide residue in medicine products by GC
Posted: Fri Oct 31, 2014 7:53 pm
by Don Shelly
Here's a thought. Homogenize the sample is water, since the analyte is very polar. Then extract using headspace combined with heat, possibly with NaCl and agitation too.
Re: Ethylene oxide residue in medicine products by GC
Posted: Sat Nov 01, 2014 4:51 am
by thohry
Here's a thought. Homogenize the sample is water, since the analyte is very polar. Then extract using headspace combined with heat, possibly with NaCl and agitation too.
Thanks for the input. I also think of some other solvents.
Re: Ethylene oxide residue in medicine products by GC
Posted: Sat Nov 15, 2014 6:51 pm
by AICMM
thohry,
Not much help but you might ask Retsch if they have ever seen this application. Or Markes.
Best regards,
AICMM
Re: Ethylene oxide residue in medicine products by GC
Posted: Fri Dec 05, 2014 2:37 pm
by rb6banjo
What is the identity of the polymer? Some polymers behave well as partition systems and direct headspace analysis is directly applicable. No extraction necessary. I use headspace SPME a lot for quantitative analysis of analytes dissolved in polymeric matrices. If the EO is concentrated enough, perhaps a straight static headspace analysis would work.