GC-MS Calibration

[rsa01]

Hi all,
I hope all are good.we are doing auto tune for calibration of MS. Is this enough for GC-MS calibration or any other things we need to do? please advice...

Regards
Ashok

[James_Ball]

Hi all,
I hope all are good.we are doing auto tune for calibration of MS. Is this enough for GC-MS calibration or any other things we need to do? please advice...

Regards
Ashok

What type of analysis are you doing? Regulated or research type work?

A lot depends on a application as to how you must calibrate and tune the instrument.

[rsa01]

Hi James Ball,
We are using for residual analysis (Low level up to ppb) of petroleum compounds.
Regards
Ashok

[James_Ball]

Hi James Ball,
We are using for residual analysis (Low level up to ppb) of petroleum compounds.
Regards
Ashok

If not governed by EPA or other regulations they just autotune the instrument for maximum sensitivity. If you are going to do quantitative analysis then you will need to use some type of calibration standard to calculate your linearity and detection limits, if you are just looking for a presence/absence it would still be a good idea to do a study using known petroleum standards to have an idea of what your limit of detection actually is.

[rsa01]

Thanks James ball. We are just doing quantification analysis i think auto tune is enough as per your advice.
but no need to do GC calibrations like flow,oven temperature,Injection volume calibration ?

Regards
ashok

[James_Ball]

Thanks James ball. We are just doing quantification analysis i think auto tune is enough as per your advice.
but no need to do GC calibrations like flow,oven temperature,Injection volume calibration ?

Regards
ashok

If your instrument is consistent then even if the flow or oven temperature is slightly off calibration it should still give good results.

The calibration I was thinking of is the calibration curve for the quantitation of the samples.