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GC-MS Calibration
Posted: Sun Sep 21, 2014 7:04 am
by rsa01
Hi all,
I hope all are good.we are doing auto tune for calibration of MS. Is this enough for GC-MS calibration or any other things we need to do? please advice...
Regards
Ashok
Re: GC-MS Calibration
Posted: Fri Sep 26, 2014 6:41 pm
by James_Ball
Hi all,
I hope all are good.we are doing auto tune for calibration of MS. Is this enough for GC-MS calibration or any other things we need to do? please advice...
Regards
Ashok
What type of analysis are you doing? Regulated or research type work?
A lot depends on a application as to how you must calibrate and tune the instrument.
Re: GC-MS Calibration
Posted: Sat Sep 27, 2014 6:21 am
by rsa01
Hi James Ball,
We are using for residual analysis (Low level up to ppb) of petroleum compounds.
Regards
Ashok
Re: GC-MS Calibration
Posted: Mon Sep 29, 2014 5:45 pm
by James_Ball
Hi James Ball,
We are using for residual analysis (Low level up to ppb) of petroleum compounds.
Regards
Ashok
If not governed by EPA or other regulations they just autotune the instrument for maximum sensitivity. If you are going to do quantitative analysis then you will need to use some type of calibration standard to calculate your linearity and detection limits, if you are just looking for a presence/absence it would still be a good idea to do a study using known petroleum standards to have an idea of what your limit of detection actually is.
Re: GC-MS Calibration
Posted: Tue Sep 30, 2014 7:03 am
by rsa01
Thanks James ball. We are just doing quantification analysis i think auto tune is enough as per your advice.
but no need to do GC calibrations like flow,oven temperature,Injection volume calibration ?
Regards
ashok
Re: GC-MS Calibration
Posted: Tue Oct 14, 2014 8:40 pm
by James_Ball
Thanks James ball. We are just doing quantification analysis i think auto tune is enough as per your advice.
but no need to do GC calibrations like flow,oven temperature,Injection volume calibration ?
Regards
ashok
If your instrument is consistent then even if the flow or oven temperature is slightly off calibration it should still give good results.
The calibration I was thinking of is the calibration curve for the quantitation of the samples.