Determination of sodium metabisulfite in parenteral formula
Posted: Thu Sep 04, 2014 7:11 pm
Hi all,
Please can any one help me with the HPLC method for determination of sodium metabisulfite in parenteral formulations. I have tried with RP-HPLC method using agilent CN column, mixture of terabutylammonium hydrogen sulfate buffer: Acetonitrile as mobile phase and using water as diluent for dissolving sodium metabisulfite. My peak responses were changing from injection to injection. Tried using other solvent to dissolve but nothing worked.
Thank You in advance.
Please can any one help me with the HPLC method for determination of sodium metabisulfite in parenteral formulations. I have tried with RP-HPLC method using agilent CN column, mixture of terabutylammonium hydrogen sulfate buffer: Acetonitrile as mobile phase and using water as diluent for dissolving sodium metabisulfite. My peak responses were changing from injection to injection. Tried using other solvent to dissolve but nothing worked.
Thank You in advance.