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Robustness test for Related Substance

Posted: Mon Aug 25, 2014 4:42 am
by jayroseville58
Can I use Change in Detector for Robustness Test? Is it okay if I'm going to use PDA detector first and changing it into 2487 UV/VIS detector? Thanks.

Re: Robustness test for Related Substance

Posted: Wed Aug 27, 2014 8:54 pm
by dlbenach
I would say no. Changing the detector is changing the method. Robustness should only alter the method conditions.

Re: Robustness test for Related Substance

Posted: Tue Feb 24, 2015 1:14 pm
by max_planck
Can I use Change in Detector for Robustness Test? Is it okay if I'm going to use PDA detector first and changing it into 2487 UV/VIS detector? Thanks.
Of course you can! This way you will have established method robustness over both UV-detector models. Especially in the future as you might need to transfer the method to another laboratory with PDA/DAD detectors only.