How to remove P-80 and PEG300 before analysing formulatin

[bobby12]

I have to analyze formulation using ESI mass spec. I have 2.5% Polysorbate 80 and 10% PEG in it. How do I remove them and analyze my API and impurities. I am worried it might contaminate or cause ion suppression in mass spec.

Is there a way to elute them in one or two min and divert first two min in waste?

[JMB]

You should look into Turbulent Flow Chromatography, which is used to separate unwanted matrix components from analytes.