Chromatography Forum

So for all of you chromatographers out there working in Quality Control or some type of heavily regulated environment. Can I start a discussion on integration settings?

I am having issues explaining how performing manual integration for every injection to correct for a baseline to baseline integration is “playing with the data”. In my mind the most accurate would allow the chromatography system to integrate, and correct only when something “weird” comes into play.

What are your thoughts/experiences with regulators?

Thanks for all of your feedback!

Tim

Check out this thread from three weeks ago:
viewtopic.php?f=1&t=21234&start=15

We try to adjust our integration parameters to get the most peaks integrated automatically, but there is always times when manual integration is needed. In our work with EPA/NELAC accreditation, as long as you document why you needed the manual integration and have a Standard Operating Procedure to cover such manual integration events stating how and why they should be performed then the auditors do not find a problem.

Be sure to add into the document that clipping or stretching peaks to make them pass QC goals is strictly forbidden, that will also help satisfy auditors.