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Why only HCL used in acid forced degradation study in HPLC ?

http://www.chromforum.org/viewtopic.php?t=23598

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Why only HCL used in acid forced degradation study in HPLC ?

Posted: Mon Oct 14, 2013 12:30 pm
by babaso_tawase
Why not HNO3/ H2SO4 not used in acid forced degradation study in HPLC assay/Rs method? Why Only HCL used?

Re: Why only HCL used in acid forced degradation study in HP

Posted: Mon Oct 14, 2013 2:08 pm
by Meerkat
It is customary to use 1N HCl and/or 1 N NaOH as degradants is FD studies because these are simple and 'strong' oxidizing/reducing reagents; furthermore, they are both mono-protic/hydroxyl and do not present additional side reactions that inhere with poly-ionic reagents. Additionally, they are both inexpensive reagents to prepare in-lab.
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