Diclofenac Potassium Assay

[rojitea]

Dear All,

Please help if any body has an Assay by HPLC method & sample preparation as well for Diclofenac Potassium Soft

gelatin capsules.

Regards,

Roji.

[awnichem]

you can look it up in USP for active substance with allowed modifications.
best regards

[rojitea]

We have tried using USP method for tablets but ot very sucessful in sample extraction as ours is a soft gelatin formulation.

We have a doubt that the drug is not getting extracted out from the gelatin shell.

[krickos]

Hi

Have you looked at the Diclofenac sodium tablets sample preparations as well in USP? One of them includes heating and chilling in order to improve extraction from "waxy materials".