Silanizing of glassware

[LCFan]

Dear all,

in a very old publication, I read:

All the glassware used for this work was silanized with dichlorodimethyl silane.

Did anybody already perform such silanization? How shall I concretely do this?

Thank you very much for every hint.

Florian

[geget]

Hi,

In our lab, to avoid silanization, we use borosilicate glass. In our case, it's to avoid adsorption of cannabinoids to the glass container during extraction.

A procedure of silanization :
Prepare a solution of diméthyldichlorosilane (Sigma D-3879) at 5% in toluene
Introduce this solution in the glass container and shake 10 min
Rince with toluene
Rince with methanol
Rince with toluene
Rince with methanol
Dry 20 min at 80°C

[LCFan]

Dear geget,

thank you very much for your solution; I will try this procedure.

Florian

[katewinslet]

I use phenyl boronic acid for 3-mpcd (I am starting to anyways I switched from the AOAC bases HFBI method). It is specific for 1,2 and 1,3 diols and water makes no difference. I dissove 5g in 19ml acetone with 1ml H2O

[Steve Reimer]

I have done it many times. 2% dichlorodimethylsilane in hexane rinse over the glassware surface to be protected, then allow to dry. For very sticky compounds, repeat the process.
I was able to keep diquat from sticking to glass. It also works for reactive pesticides on glass wool inserts, although not as well as commercially prepared products.