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Estimating new compound pKa using HPLC

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Estimating new compound pKa using HPLC

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KarenJ
Hi,

Can anyone describe the procedure for measuring an approximate pKa of a sample compound using HPLC? If anyone has a good reference for this method that would be really helpful as well.

Thanks,

Karen J

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Uwe Neue
Lipophilicity and pKa estimates from gradient high-performance liquid chromatography
Journal of Chromatography A, Volume 965, Issues 1-2, 2 August 2002, Pages 117-127
Roman Kaliszan, Piotr Haber, Tomasz Bczek, Danuta Siluk and Klara Valko
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