Chromatography Forum

I know this sounds strang, but does anyone have experiences on quantitation of Sodium permagnate using HPLC system? What kind of detector i should use for that?

It does sound strange. Why not just titrate?

The marketing team just gave a quote to a client with this suggestion, using HPLC to quantify sodium permagnate in a mixture of organic chemicals. I have no choice but to go along with the decision. Besides, the columetric method might be too labor intensive.

I have seen/read a method for ammonium ions using ion exchange column equipped with a ion detector (http://www.google.com/search?hl=en&lr=& ... ia*tobacco). I was wondering if simular approach can be done using ion exchange column for permagnate.

Since the company doesn't have any ion detector available, what other choices i have for the detector?

Suggestions?

You can do quantitation either using UV (permaganate ion) or ELSD (both sodium and pemanganate) we have a few application for simultaneous guantitation of organic and inorganic compounds.
If you would like to retain pemanganate you need anion exchange column.
For sodium you need cation-exchange column. You can retain both of them on mixed mode Primesep AB column. I will see tomorrow if we have pemanganate in the lab. May be we can do a fast method for you.

You can also check the following links:

http://hplcmethods.com/compound_081.php (sodium, zinc, chloride, etc.)

http://hplcmethods.com/compound_018.php (ions along with dextromethorphan)

You can also download the brochure about determination of ions along with organic compounds:
http://allsep.com/brochures/PrimesepIC_Rev3.pdf

And poster for "Simultaneous Separation of Organic and Inorganic Compounds in Single HPLC Run"

http://allsep.com/brochures/OrganicInorganic.pdf

Regards,

Vlad

If this is permanganate it is violet and, threfore, also absorbs in the visible.

pochengjean,

I would stay away from HPLC for quantitation of permanganate. There's not much chance of it making it through a column intact. It will decompose quantitatively when retained via anion exchange (at least when the retention site is organic as in the case of Primesep)!

Producing Primatenonsep?