Chirobiotic T polar ionic mode
Posted: Fri Jun 14, 2013 3:46 pm
I have a general question. I'm trying to resolve a racemic compound using the polar ionic mode. I start to see a hint of separation at 2:1 acid:base ratio, but adjusting this ratio doesn't seem to have an effect on selectivity. I read that for this mode selectivity is governed by acid base ratio so I'm trying to find out why it doesn't seem to affect it here. thanks.