Chromatography Forum

I am new to this forum - so sorry if this subject was discussed before

Is anybody out there with view on use of about 0.2% perchloric acid in mobile phase?

there are many references in literature and people use it without any problems but we seem to have some visible damage to our MS source on one of our TOF machines – and at the moment we can only think about perchloric acid being the cause of it.

Is it possible that similar e damage is caused in LC systems - any view on this?

Many thanks

Quick search of forum gave this:
viewtopic.php?t=6778

I have experience from using 0.5 % perchloric acid in mobile phase. However, this was used with HPLC-UV and on a Organic acid column (Styrene divinylbenzene phase). This works fine for us.

Sassman's original reply in the forum krikos found is probably correct. An oxidising acid in a spray chamber at 300 degrees C or more will be much more harmful than the same acid calmly pootling through an HPLC system at 30 degrees.