Chromatography Forum

I'm setting up a new preparative GPC using an RI detector and I'm wondering if I should be using stabilized THF. Since I'm not using a UV-Vis detector, I don't have to worry about BHT interference. The biggest problem I'm having is recovering fractions from the GPC since drying the unstabilized THF produces peroxides. Any help or advice would be greatly appreciated!

At my last position, we used stabilized THF, mainly for safety reasons - our safety department didn't want to take a chance with peroxides forming in solution.

Also the price difference is not that much, I would suggest you use stabilized THF if you are going to be recycling the eluate. Your safety is worth more than a few bucks saved!