assay by titrimetry issue
Posted: Mon Apr 22, 2013 7:03 am
Dear All,
This is related to Etodolac assay by titrimetry. In EP/USP monograph, potentiometric titration is given vs. 0.1 M tetrabutyl ammonium hydroxide in methanol/toluene. We are getting results on higher side varying between 110-115%.Normality calculated potentiometrically for the solution in triplicate is consistent. Electrode bein used for the titration is Metrohm 6.0229.100(pH electrode LiCl sat.in EThanol). The same titration carried out vs. 0.1M sodium hydroxide using pH electrode is giving consistent results. Has anybody experienced this kind of issue in the titration . Pl. guide.
This is related to Etodolac assay by titrimetry. In EP/USP monograph, potentiometric titration is given vs. 0.1 M tetrabutyl ammonium hydroxide in methanol/toluene. We are getting results on higher side varying between 110-115%.Normality calculated potentiometrically for the solution in triplicate is consistent. Electrode bein used for the titration is Metrohm 6.0229.100(pH electrode LiCl sat.in EThanol). The same titration carried out vs. 0.1M sodium hydroxide using pH electrode is giving consistent results. Has anybody experienced this kind of issue in the titration . Pl. guide.