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Determination of Chloroacetic acid
Posted: Tue Apr 16, 2013 6:58 pm
by chemistab
Can someone help me how i can determine the chloroacetic acid?? How possible is to succeed to determine chloroacetic acid by GC-FID?
I wait for your answer!!!
Re: Determination of Chloroacetic acid
Posted: Wed Apr 17, 2013 12:07 am
by jss37992
A simple methylation will allow you to determine Chloroacetic acid by measuring it in its methyl ester form. Theoretically, if all of the Chloroacetic acid is methylated then you would assume the amount of methyl ester that is measured is equal to the amount of Chloroacetic acid in the sample. Try looking up EPA 552 for the extraction procedure. These methods are meant to be analyzed using an ECD but you should still get a response on an FID. Hope this helps!
Re: Determination of Chloroacetic acid
Posted: Wed Apr 17, 2013 1:06 pm
by jdezeeuw
I do not have any GC-chromatogram to share, which already tells me it is not an easy task. Best way is, as stated in previous answer, to use a methylation.
If you want to try to analyze it without derivatization, use a thick film (like 5 microns of an Rtx-1 type phase on 0.32mm).
be aware of liner inertness as such compounds tend to stick also in the liner.
jaap de zeeuw, Restek corporation