Chromatography Forum

Recently I was given several racemates to try to resolve using chiracel columns. I don't have experience with chiral separations but was still able to resolve several of them. The compounds giving me fits are ones containing two primary amines. For proprietary reasons I can't give the specific structures of these compound, but they contain 2 aromatic rings 2 primary amine substituents. With this limited information can someone suggest a csp that may have a good chance to resolve amines? I've tried several columns and either get a massive blob or no elution. Suggestions welcomed.

Also any links to good information on chiral techniques would be appreciated.

How hydrophobic or hydrophilic are the enantiomers?

Probably more to the hydrophobic side. Not soluble in 100% water, soluble in EtOH though.

I would just call Chiral tech. They could probably find the right column for you.

I think Regis will even test your compound for you and find one that works.