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- Posts: 33
- Joined: Sat Jan 15, 2011 2:53 am
This is a lyophilized drug and suppose to be reconstituted with water before administered.
Why is the known impurity recovery low at low level? I can only think of two reasons: 1 impurity was binding with mannitol, 2: impurity was not completely dissolved. Either way I think I should look into sample preparation? maybe sonicatethe sample (the sample was not sonicated at the time of prep)?
Pleas advise on how do I improve the recovery? and what could be the reason.
Thanks.