Chromatography Forum

I have a problem in analysis of slight amount of 2-propanol dissolved in DMF(N,N-dimethylformamide)/water(1/1) using GC system with a Supelco OVI-G43 column. Solvent blank injection shows an impurity peak near 2-propanol at about 7min. The impurity peak area depends on preparation conditions of the mixture of water and DMF. When the mixture is prepared in not-cooled condition (the mixture gets warm). the peek area gets larger. I prepared the mixture in cooled condition to minimize the impurity peak area. But, yet a small peak of the impurity interfered the determination of 2-propanol. There would be a possibility of hydrolysis of DMF in the preparation, and also in the injector at 200 degree.
Anyone experienced such problem? Any solution?

How about trying a different solvent to dissolve your matrix for the analysis of ipa content?

Try DMAc instead of DMF. OR

Try using pyridine water instead of DMF and water.

I doubt you will ever be able to eliminate totally the peak you describe from the reaction of combining DMF and water.

Use another column for the analysis...... How about porapak Q packed column

or a carboxwax 20M?

good luck