Chromatography Forum

I have a some question in chemistry?may be wrong to put this in this forum but i felt some chemist can help me.
1)how to know whether the compound may get degraded or not by looking into structure?
2)how to identify whether the compound has fluorescent property or not with the structure?
thanks in advance.

First, You might get better response if this is posted in the student projects or arround the water cooler portions of the site.

Degredation - degredation is a chemical reaction. In the out door environment, this may commonly include various kinds of oxidation or hydrolysis. In the body, there are more complex reactions that will result in the degredation of a compound. Depending on conditions, just about everythign can be degraded.It is a question of what kind of environment and what kind of compound.

Fluorescence is really hard to spot unless you recognise a group that looks almost identical to some other chemical that you know fluoresces. Merely having large conjugated systems that are appropriate for absorbing light doesn't mean something will have fluorescence, since fluorescence requires that it can't lose the photon energy just by vibrating a lot and gently wobbling its way back down to a low energy level again. It's not clear what makes the difference (I asked a good chemist and they got reaaaally embarrassed that they couldn't find an answer until they Googled it and found an even better chemist saying it's really hard to tell).

Degradation is even harder to spot. Some chemicals are obviously unstable (have groups that you know will hydrolyse at the least drop of water; are so strongly light-absorbing that they will probably photo-degrade). But other chemicals are very tricky and require an expert knowlege of their chemistry. My favourite example is bicarbonate: why on earth does it degrade to carbon dioxide on contact with acid? Everyone knows it does... there is an explanation, and it's very, very far from simple.

thank you.Is there is any chance for Patulin,Cyclopiazonic acid and Mycophenolic acid(three toxins) can be degraded in the buffer of different pH.

There's a chance... and there's a fairly standard way of finding out once you've found a stability indicating method for assaying each of these.

Look up "forced degradation studies".