I am currently working on trying the transition myself. Still having trouble with volatiles passing a BFB tune, but made the changes Agilent recommended and trying some more. The only problem so far has been getting the m/z 96 to m/z 95 ratio below 9%. Will be trying it soon on semivolatiles with the DFTPP tune criteria. No problems with the volatiles so far except this.
The Thermo webinar said they had to bake out the source with a high flow of H2 overnight, something like 4ml/min at 350c to get the ratio to fall into a passing range.
I had 96 down to 16% last week but cleaned the source and switched to the larger diameter drawout plate and went to the 0.18mm column and now it is back up to 50%. Previously it started at 80% and dropped to 16% after a week of running test samples. Something bakes out over time that is causing the problem I hope we can get it into passing range so we can make the switch.
If you are not under EPA tuning criteria then it probably would not be such a bad transition as long as you look at new ion ratios for your targets, just need to run standards and update the ratios. The ion gauge does read higher than with Helium but as long as you keep the reading below 6*10^-5 torr you should be ok with flow.
