Chemstation calibration update and reprocess.

[BCBC]

Sometimes when I analyze a calibrator, update calibration and reprocess I get quantitation value that does not agree with my quant. table value. I may have 15.00 ng/ml in the quant. table but get 14.99 or 14.98 after updating calibration and running the method to reprocess. This is using Chemstation. Ver. D.02 or D.01. Drug mode. Any thoughts?

[Yama001]

Sometimes the update in retention times results in the software extracting a portion of the ion chromatogram over a slightly different time range. This can cause a minor change in baseline, peak slope detection, etc.

Note this only applies for a single point calibration; if you can get exact values returned from a multiple level calibration I am impressed.

[BCBC]

Thank you.