Chromatography Forum

I have a Waters UPLC and usually use a waters inline filter before the column but they are not compatible with Dionex as the thread buckles.

Can anyone suggest another inline filter that may be compatible with Dionex columns?

Oh and preferably THF compatible also

You're referring to the Acquity UPLC inline filter unit? The holder with 0.2µm filter discs? Why should it not be compatible with Dionex columns? I've used it on non-Waters UHPLC-Systems on a range of non-Waters columns without problems (no Dionex column, though ). You just have to make sure you'll use a fresh new holder for each column of different manufacturers since the ferrule is swaged on the connection tubing the first time you use it.
There are inline-filter solutions from other manufacturers, but I don't have any experience with them. We use the SecurityGuard Ultra (? I think that's the name, would have to check) from Phenomenex for some methods. This is not a plain filter but a universal guard column, though.

Ah, yes, I'm not affiliated with Waters or Phenomenex .

Thanks for the feedback, I will try using a fresh inline filter on the column and see if that works, I did try and put the inline filter on the sample outlet of the rheodyne injector, which seems to be working.