pH adjustment in dextromethorphan Hbr as per EP

[anandaraohs]

Hi

For the preparation of Dextromethorphan HBr EP mobile phase to attain the pH of 2.0 lot of acetic acid will consume there by total mobile phase composition will vary.(Ex;For 1000 ml approximately 150 to 200 ml acetic acid will consume)

Thanks and regards
Anand

[syk10148]

Yes, that is true. I've experienced the samething as well however it worked at the end. Give it to go. It will be fine.