Glycols method for GCMS or UPLC?

[seamoro]

Any body know of any methods that work for the analysis of glycols such as ethyleneglycol-monobutyl-ether, ethylenglycol, dipropylene, 1,3 propanediol, triethylene, propylene, diethylene glycol? Im taking over a project and supposivley the analysis of these was already tryed with GCMS but the method was too troublesome with carry over. Im looking at hplc methods and i see some with derivation , anybody any experience of this? any suggestions..thanks

[Jetjamnong]

All compouds have -OH group, which can derivatise by BSTFA or MSTFA and GC/MS analysis.
See this link for reference journal and adapt it to your work.
http://www.springerlink.com/content/6k10602kn3322604/

[AICMM]

seamoro,

Glycols have been discussed a bit on the forum. Take a search. Can be done by GC with an FID and carbowax but not the prettiest thing in the world. Be very careful about water if you think about GC/MS, very hard beast to pump out of your system. Cannot be done without derivatization by HPLC since no sensitive detector for these constituents (at least as I see it...)

Best regards,

AICMM

[Consumer Products Guy]

We've derivatized these with BSTFA and assayed by GC and GCMS for two decades or more.

Also, the MS spectra of these materials are much more definitive when derivatized than non-derivatized.