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PFPA and BSTFA

Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.

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PFPA and BSTFA

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adsfo
Is there any concern running PFPA and BSTFA derivatives on the same GC/MS (same column)? A while ago I read somewhere that there can be some cross reactivity between those two derivatizing agentns leading to rapid column degradation.

Re: PFPA and BSTFA

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bird
The by-product of PFPA is an acid, and that is the main culprit for column degradation.

BSTFA is a much better choice for fused silica columns, as it can potentially aid in repairing it.
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