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Impurity caculation using RRF
Posted: Tue Jul 17, 2012 9:39 am
by pjalindar
is RRF multiply or divide to calculate impurity
Re: Impurity caculation using RRF
Posted: Tue Jul 17, 2012 9:51 am
by imran_ali_qu
Yes it is very essential to keep the RRF for impurity calculation. and it will divide from calculation..
Re: Impurity caculation using RRF
Posted: Tue Jul 17, 2012 12:59 pm
by HPLCaddict
It depends on how you calclulated the RRF. May be both ways...
Re: Impurity caculation using RRF
Posted: Tue Jul 17, 2012 2:22 pm
by tom jupille
As HPLCaddict pointed out, it can be defined either way.
If it is defined as the RRF of the impurity (the most common situation), it is used as a divisor. In that case, the RRF is ratio of responses: Impurity/Parent. Let's suppose your impurity has an RRF of 0.5. That means that for equal amounts, the impurity peak will be half as big as the parent peak. You divide by the RRF to correct for that.
If it is defined as the RRF of the parent, then you would multiply.