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Stability-indicating method: oxidation with O2/AIBN
Posted: Mon Jun 25, 2012 7:37 am
by LCFan
Hello,
I am planning a forced degradation study using Azo-bis-(isobutyronitril) as an initiator within the oxidative treatment with O2.
Is there anybody who ever did this and could give me safety recommendations?
Thank you very much.
Florian
Re: Stability-indicating method: oxidation with O2/AIBN
Posted: Mon Jun 25, 2012 11:19 am
by prepcolumn
Hello,
I am planning a forced degradation study using Azo-bis-(isobutyronitril) as an initiator within the oxidative treatment with O2.
Is there anybody who ever did this and could give me safety recommendations?
Thank you very much.
Florian
Florian
AIBN is a safe radical initiator (safer than peroxides), it only gives out nitrogen gas (nevertheless safety is first). It is organic soluble and i think decomposes after 70-75 degrees celcius. That's why you don't have to overheat your samples
Hope this helps
Re: Stability-indicating method: oxidation with O2/AIBN
Posted: Mon Jun 25, 2012 2:13 pm
by LCFan
Dear prepcolumn,
thanks a lot for your reply; I am glad about these facts.
Are you also experienced in the use of ACVA (4,4'-azobis(4-cyanovaleric acid))? Does it behave similar?
Regards
Florian
Re: Stability-indicating method: oxidation with O2/AIBN
Posted: Mon Jun 25, 2012 2:55 pm
by prepcolumn
Dear prepcolumn,
thanks a lot for your reply; I am glad about these facts.
Are you also experienced in the use of ACVA (4,4'-azobis(4-cyanovaleric acid))? Does it behave similar?
Regards
Florian
Florian
I didn't use ACVA before but to the best of my knowledge it is water soluble and more flammable
Regards