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- Posts: 4
- Joined: Thu Dec 22, 2011 4:15 pm
hi,
i am trying to make paracetamol suspension hplc method,that contains paracetamol+methyl paraben
for assay: i used C8X150X4,6X5mcron, 50/50 acn and %1TFA , method was good for assay but at specificty test, i spiked 3 known impurity that recorded at EP , one of them was under paracetamol and the other was under methyl paraben,
is there any method parameters that i can seperate impurities and have specificity , also i can use these method for impurity analysis,
Thanks
i am trying to make paracetamol suspension hplc method,that contains paracetamol+methyl paraben
for assay: i used C8X150X4,6X5mcron, 50/50 acn and %1TFA , method was good for assay but at specificty test, i spiked 3 known impurity that recorded at EP , one of them was under paracetamol and the other was under methyl paraben,
is there any method parameters that i can seperate impurities and have specificity , also i can use these method for impurity analysis,
Thanks
