Issues with IC Cationic Suppressor Method

[Labmonkey]

Have no end troubles with an ion exchange method for Bethanechol Chloride (USP related susbstances method) using a Dionex cationic suppressor fitted to a shimadzu CDD-10AVP conductivity meter. Have issues with stable baseline, and seeing the peak of interest consistently when a have the suppressor operating and turned off. Have very little experience with the conductivity meter and suppressor, any help any one could provide would be very much appreciated

[Markus Laeubli, Metrohm]

We use non-suppressed IC for that application (see AN C-120). Your conductivity detector should be able to cope with the background and its thermal stability.