Chromatography Forum

Chromatography Forum is a public discussion group where you can post questions, news, or messages of interest to chromatographers everywhere, but you must be registered to participate (registration is FREE). If you are a registered user, please log in.
http://www.chromforum.org/

HILIC separations - can they be modelled by DryLab?

http://www.chromforum.org/viewtopic.php?t=19771

Page 1 of 1

HILIC separations - can they be modelled by DryLab?

Posted: Tue May 01, 2012 3:23 pm
by Rob Burgess
.... or is the separation mechanism too complex to understand or does not follow a strict linear solvation energy relationship?

Also, is it possible to perform gradient separations with HILIC?

Re: HILIC separations - can they be modelled by DryLab?

Posted: Tue May 01, 2012 3:36 pm
by tom jupille
To take those in reverse order:

Yes, gradients can be used in HILIC. Phenomenex has a good example on page 14 of their Luna HILIC brochure:
http://tinyurl.com/7mcwy5n

Re DryLab, HILIC is essentially normal-phase liquid-liquid partition chromatography. The "normal phase" mode of DryLab should do OK for that. If you want to play with it, the DryLab 2000 versions had a "custom mode" capability that would let you pick your own fitting function (I'm ot sure if that carried over into the later versions, though).
All times are UTC
Page 1 of 1
Powered by phpBB® Forum Software © phpBB Limited
https://www.phpbb.com/