Decreasing response of GCMS

[chandra]

My dear friends hello to all of you.
I absorbed one thing during the autotune of my GCMS,the response of the ion is decreasing gradually. Can this will effect my chromatograms,if so than what should i do ?


Chandra

[Alexandre]

It will affect sensitivity. You need to check that you still have the DL you need.
As soon your acceptance criteria fails you need to clean the instrument in order to restore sensitivity. You should see increase of ion counts in tune after that. If this did not happen it may be that the detector/multiplier is dying, you need to change it. Depends on usage, most labs change it every ~5 years.