Chromatography Forum

Chromatography Forum is a public discussion group where you can post questions, news, or messages of interest to chromatographers everywhere, but you must be registered to participate (registration is FREE). If you are a registered user, please log in.
http://www.chromforum.org/

Suitable Internal Standard for Tramadol HCl

http://www.chromforum.org/viewtopic.php?t=1893

Page 1 of 1

Suitable Internal Standard for Tramadol HCl

Posted: Wed May 04, 2005 7:21 am
by syx
Dear Members,

Does anyone have an idea what substance is suitable to be internal standard for RP-HPLC determination of Tramadol HCl, C16H26ClNO2, in suppositories dosage form?

(1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol . HCl
Solubility: freely soluble in water, methanol; very slightly soluble in acetone (BP2004)
Detector wavelength: UV 270 – 271 nm

Image

Best regards,
SYX

Posted: Wed May 04, 2005 2:41 pm
by HW Mueller
Is an ethoxy compound available, or an N-ethyl? A diastereomer would probably be too different (if available).
All times are UTC
Page 1 of 1
Powered by phpBB® Forum Software © phpBB Limited
https://www.phpbb.com/