fluorinated HPLC solvents

[MestizoJoe]

Does anyone know some useful fluorinated HPLC solvents? I'm hoping to develop a precipitation dissolution HPLC method for a polymer which dissolved in only strong acids and fluorinated solvents. So far I've only tried 2,2,2-trifluoro ethanol and my material was only partially soluble. Are there some more, common solvents I can try?

[sepscientologist]

hexafluoroisopropanol is an excellent solvent for polyesters. The RI is less than that of water!
Viscosity is very low. Ability to instantly ruin your eye and lung membranes is also very high
so be careful if you use it.

[MestizoJoe]

What about hplc instrument compatability any issues?

[Sallybeetle]

You might try the precursor to 2,2,2-trifluoro ethanol. It is trifluoroacetic acid (TFA). TFA is generally HPLC, LC/MS, ELSD compatible.

Heptafluorobutyric acid (HFBA).

Pentafluoropropionic acid

These are used as ion pair reagents in reverse phased chromatography. I have had good experiences with TFA solutions as solvent and ion pair.