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- Posts: 12
- Joined: Thu Jul 31, 2008 1:40 pm
Hello,
If I am preparing a 100% methanol mobile phase (assume it is dry) and I am adding an organic acid as a modifier, does anyone know how fast the esterification reaction will be (formation of methyl formate and concomitant reduction in the amount of formic acid)? I know it depends on acid concentration, etc. but if anyone has any guidelines or a reference I would appreciate it.
Chris
If I am preparing a 100% methanol mobile phase (assume it is dry) and I am adding an organic acid as a modifier, does anyone know how fast the esterification reaction will be (formation of methyl formate and concomitant reduction in the amount of formic acid)? I know it depends on acid concentration, etc. but if anyone has any guidelines or a reference I would appreciate it.
Chris
