Use of Pepsin
Posted: Fri Dec 30, 2011 9:20 am
Dear All,
Sorry for posting dissolution query on this site…….
USP says that we can use Pepsin/ Pancreatin in case of hard gelatin capsules dissolution. So my question is :
If the pH of dissolution media is 4, then what should be sequence of pepsin addition?
Should I first set the pH of media to 4 and then add Pepsin?
or
Should I add the Pepsin into the media and then adjust the final pH of the media?
Regards
Sorry for posting dissolution query on this site…….
USP says that we can use Pepsin/ Pancreatin in case of hard gelatin capsules dissolution. So my question is :
If the pH of dissolution media is 4, then what should be sequence of pepsin addition?
Should I first set the pH of media to 4 and then add Pepsin?
or
Should I add the Pepsin into the media and then adjust the final pH of the media?
Regards