Dear All,

Sorry for posting dissolution query on this site…….

USP says that we can use Pepsin/ Pancreatin in case of hard gelatin capsules dissolution. So my question is :

If the pH of dissolution media is 4, then what should be sequence of pepsin addition?

Should I first set the pH of media to 4 and then add Pepsin?
or
Should I add the Pepsin into the media and then adjust the final pH of the media?


Regards